Posts Tagged ‘Teriparatide’

Prevent and Treat ONJ with Forteo

July 31, 2015 @ 7:54 am
posted by Dr Ginther

Dentists and Oral Surgeons are sometimes wary of their patients being on ANY Osteoporosis Medications when they undergo tooth extractions or other dental proceedures.  One osteoporosis medication is different from all the others.  Forteo is the only Anabolic medication currently available in the USA.  Forteo does not cause dental and jaw problems.  Forteo can be used to treat ONJ and other bone problems of the jaw.

OsteoNecrosis of the Jaw (ONJ) is a rare complication of tooth extraction.  If you have cancer, are on chemotherapy, have uncontrolled diabetes, or are on the higher doses of Antiresorptive Osteoporosis Medications used in Cancer Patients with Metastases, ONJ is less rare.

ONJ is the result of too slow bone repair by the OsteoBlasts (the cells that make new bone matrix).  Antiresorptive medications slow down both OsteoClasts (the cells that resorb bone) and OsteoBlasts.

Forteo cannot cause ONJ.  Forteo (Teriparatide) stimulates OsteoBlasts.  That increases new bone matrix formation.  Therefore, Forteo can prevent and treat ONJ.

Forteo has been shown to improve bone healing in dental surgery, including implant osseointegration and healing alveolar defects.  Ref:  Batshutski JD, Eber RM, Kinney JS, et al.  Teriparatide and osseous regeneration in the oral cavity.  N Engl J Med. 2010, 363:2396-2405.  Ref:  Kuchler U, Luvizuto ER, Tangl S, et al.  Short-term Teriparatide delivery and osseointegration: a clinical feasibility study.  J Dent R. 2011:90(8):1001-1006.

As a former orthopedic surgeon, I have discussed these issues with several of our local oral surgeons and dentists.

If you are facing oral surgery or tooth extraction, discuss your osteoporosis medications with your dental surgeon.  Most osteoporosis medications should be held for your surgery.  Forteo is the exception.  Forteo actually helps your jaw heal after dental surgery.

Jay Ginther, MD

“Bisphosphonate Holiday” 2014

March 8, 2014 @ 8:56 pm
posted by Dr Ginther

“You are entering a Data-Free Zone”   That was unfortunately the messasge at the joint meeting of the International Society for Clinical Densitometry (ISCD) and the International Osteoporosis Foundation (IOF) last month.  We simply do not have data from a study involving tens of thousands of patients.  We do know some things that are helpful.

Bisphosphonates build up in bone over time.  After about 5 years of Bisphosphonate therapy, you should have enough medication in your bones to last for additional years.  How many years?  That depends.  Different individuals lose Bisphosphonates from their bones at different rates.  Different Bisphosphonates tend to stay in bone longer or shorter than others.  We call the time you are able to stop taking medication for a while (because you have enough in your bones already) “Bisphosphonate Holiday”.

Beware of GIOP

April 1, 2013 @ 5:55 am
posted by Dr Ginther

GIOP is Glucocorticoid Induced OsteoPorosis.  Cortisone, Prednisone, and many Inhalers for Asthma or COPD are glucocorticoids.  Therefore, Glucocorticoid Induced OsteoPorosis is a particularly aggressive form of osteoporosis that affects all ages, not just older adults.

Glucocorticoids suppress OsteoBlasts, the cells that make new bone.  Even the normal rate of bone turnover required for good bone maintenence and repair of microcracks becomes a problem when new bone formation is suppressed.  Persons with GIOP have a rapid decline in bone quality and strength.  What can be done?

No Human Osteosarcoma Linked to Forteo

December 29, 2012 @ 10:44 pm
posted by Dr Ginther

A reader has asked about bone cancer and Forteo.

Osteosarcoma is a rare bone cancer.  Lilly has endowed a 15-year independent study (suggested by the FDA) of all Osteosarcoma patients in Cancer Registries, looking for individuals who have taken Forteo.  The halfway point results from June 2004 through Sept 2011 were published in JBMR in Dec 2012.  Of the 1448 persons who had Osteosarcoma during that time period, not one had taken Forteo.

The “black box” warning on the Forteo (Teriparatide) label refers to studies of rats, not humans.  These rats very commonly get osteosarcoma without any medication.  The rats were given doses 3 to 20 times the human dose for the equivalent of 70 human years.  Rats’ bones never stop growing.  Growing bones are particularly vulnerable to osteosarcoma.  Humans are different from rats.