Posts Tagged ‘Osteoporosis’
“Real Men Build Their Strength from Within” is this year’s campaign by the International Osteoporosis Foundation. Today is World Osteoporosis Day for 2014, and the beginnning of the international campaign.
Men have Osteoporosis too, although they are only half as likely as women to be treated, even after a fracture.
One third of all hip fractures are in men. And a man is twice as likely as a woman to die of complications of his hip fracture.
Use the Links to the upper right to go to the International Osteoporosis Foundation website. Visit National Osteoporosis Foundation too.
Then get a Complete Bone Health Evaluation, and Take Control of your bone health.
Jay Ginther, MD
Forteo is a daily shot. That is a nuicence, but a small price to pay for the only Anabolic, the only osteoporosis medication which will increase bone mass in spongy (cancellous) bone. Diabetics give themselves a daily shot for the rest of their lives. Forteo is for only 2 years and uses a tiny insulin needle.
People worry about the warning that lab rats got Osteosarcoma after being given very high doses of Teriparatide for the equivalent of 70 human years. We have not seen this in humans, or chimps, or monkeys, or dogs. Rats have bones that grow all their lives. We do not give Forteo to growing humans, pregnant women, nursing women, persons with Paget’s Disease or unexplained elevated Alkaline Phosphatase, or persons who have had radiation to their bones.
Remember that you must take adequate Calcium, with food, spread out over 3 meals. You must take enough Vitamin D3 to be able to absorb Calcium. You must eat enough Protein for your OsteoBlasts to make new bone matrix.
Forteo (Teriparatide) increases the thickness of the struts making up spongy (cancellous) bone. Forteo is the only osteoporosis medication to do that. It also makes the hard outer shell (cortical bone) thicker. How? Forteo stimulates OsteoBlasts. They make bone matrix, the collagen protein that is more than 80% of bone.
Forteo also stimulates bone turnover. Healthy bone is constantly being resorbed and replaced. This allows bone to eliminate the micro-cracks that gradually accumulate with activity. Bone is strongest when it is a mixture of older more calcified (stiffer) material mixed thoroughly with younger less calcified (somewhat bendable) material. Cracks cannot enlarge. Strength is better. More force is required to fracture the bone.
Denosumab (Prolia) mimics the natural process that keeps OsteoClasts (the cells that gobble up bone) under control before menopause. OsteoCytes release Osteoprotegrin (OPG) when Estrogen (or Testosterone) is on board. OPG controls the formation and activation of OsteoClasts by blocking RANK-Ligand, which is necessary for OsteoClast formation and activation. This decreases fracture risk.
Prolia mimics OPG and blocks RANK-Ligand, thus blocking bone resorption by preventing OsteoClasts. It is a RANK-Ligand Antibody. It is like birth control for OsteoClasts. Prolia is given as a shot under the skin twice a year. Prolia is very effective at first, but begins to fade by 6 months. Without another injection , Prolia has totally lost effectiveness by 12 months after the last shot.