Posts Tagged ‘Osteoporosis’

Denosumab – Prolia – OPG Analog

August 21, 2014 @ 8:17 pm
posted by Dr Ginther

Denosumab (Prolia) mimics the natural process that keeps OsteoClasts (the cells that gobble up bone) under control before menopause.  OsteoCytes release Osteoprotegrin (OPG) when Estrogen (or Testosterone) is on board.  OPG controls the formation and activation of OsteoClasts by blocking RANK-Ligand, which is necessary for OsteoClast formation and activation.  This decreases fracture risk.

Androgen Deprivation Therapy – ADT

August 1, 2014 @ 5:16 pm
posted by Dr Ginther

Androgen Deprivation Therapy is used to treat Prostate Cancer.  ADT is usually effective against Prostate Cancer, adding years to a man’s life.  However, ADT can cause Osteoporosis and Fractures, UNLESS we treat to Prevent Fractures.

The good news is that we can decrease Fracture Risk by more than half.  Plus, the medication which preserves bone can help treat the cancer!  We can usually delay, and sometimes prevent, metastases to bone.  Occasionally we can shrink the original prostate cancer tumor.  Amazing!  You can Take Control.

Bisphosphonates are the most commonly prescribed Antiresorptive medications used to prevent or treat Ostoeporosis.  We know them as Fosamax (Alendronate), Boniva (Ibandronate), Actonel (Risendronate), Atelvia (enteric coated Risendronate), and IV Reclast (Zolendronate).  All but the last are pills taken weekly or monthly.

If your bone is strong enough that preserving it is sufficient to prevent fractures, then Antiresorptive medication is what you need.  If you are able to follow the protocol of taking the pill on an empty stomach, followed by one or more full glasses of plain water, and eating or drinking nothing else for at least 30 minutes (60 for Boniva) while remaining upright, Oral Bisphosphonates are the medication for you.