Posts Tagged ‘osteoclasts’
The FDA has approved Prolia for men with osteoporosis, who are “at high risk for fracture”. This affects a sizeable number of men. High fracture risk includes men with crumbling spine “humpback” vertebral fractures (kyphosis), other fractures (especially hip), inhaler and other steroid use, parental history of fractures, and smoking. See the posts about these topics and FRAX.
Prolia is especially useful in individuals with Heartburn or Reflux Disease (GERD) and decreased kidney function, including many older individuals with older, tired kidneys. Women have had Prolia available since 2010. Having this additional option for men is important.
Human Estrogen is the natural means of preventing bone loss before menopause in women. The huge drop in estrogen levels during menopause leads to increased bone loss during and after menopause.
Estrogen stimulates the formation of Osteoblasts (the cells that make new bone). Estrogen lengthens the lifespan of Osteoblasts and Osteocytes (the cells that live in and maintain bone). Estrogen supresses the formation and activation of Osteoclasts (the cells that eat bone away).
Maybe you can get 2 beneficial effects with only 1 medication! Some women can with Evista (Raloxifene). Are you one of those women?
If you are at High Risk for Invasive Breast Cancer, Evista is FDA approved for prevention. If you are also at risk for developing Osteoporosis, Evista is FDA approved for prevention and treatment.