Posts Tagged ‘osteoclasts’

Prolia Is Now For Men Too!

October 1, 2012 @ 9:09 pm
posted by Dr. Ginther

The FDA has approved Prolia for men with osteoporosis, who are “at high risk for fracture”.  This affects a sizeable number of men.  High fracture risk includes men with crumbling spine “humpback” vertebral fractures (kyphosis), other fractures (especially hip), inhaler and other steroid use, parental history of fractures, and smoking.  See the posts about these topics and FRAX.

Prolia is especially useful in individuals with Heartburn or Reflux Disease (GERD) and decreased kidney function, including many older individuals with older, tired kidneys.  Women have had Prolia available since 2010.  Having this additional option for men is important.

Estrogen is Good for Bones

March 24, 2012 @ 11:00 pm
posted by Dr. Ginther

Human Estrogen is the natural means of preventing bone loss before menopause in women.  The huge drop in estrogen levels during menopause leads to increased bone loss during and after menopause.

Estrogen stimulates the formation of Osteoblasts (the cells that make new bone).  Estrogen lengthens the lifespan of Osteoblasts and Osteocytes (the cells that live in and maintain bone).  Estrogen supresses the formation and activation of Osteoclasts (the cells that eat bone away).

Evista – Get 2 for 1

December 13, 2011 @ 4:01 am
posted by Dr. Ginther

Maybe you can get 2 beneficial effects with only 1 medication!  Some women can with Evista (Raloxifene).  Are you one of those women?

If you are at High Risk for Invasive Breast Cancer, Evista is FDA approved for prevention.  If you are also at risk for developing Osteoporosis, Evista is FDA approved for prevention and treatment.  

Breast Cancer & Osteoporosis

November 18, 2011 @ 9:00 pm
posted by Dr. Ginther

Breast Cancer is bad enough without further worries.  Unfortunately, the newest and best anti-cancer treatments can result in a rapid advance of Osteoporosis and Fragility Fractures.  Fortunately, acting to prevent and treat osteoporosis can slow or prevent the spread of the cancer!

We talked about these issues when I spoke to a Breast Cancer Support Group on Monday.  These are women fighting a deadly foe with strength and determination, as my mother did years ago.