Posts Tagged ‘osteoclasts’

Aromatase Inhibitors for Breast Cancer

August 24, 2014 @ 10:41 pm
posted by Dr Ginther

Aromatase Inhibitors (AI) do a great job treating Breast Cancers which are Estrogen dependent.  The AI wipe out all Estrogen thereby depriving the breast cancer of a needed stimulus.

Unfortunately, Aromatase Inhibitor treatment will also do considerable damage to your bones unless you take medication to protect your bones.  The good news is that we have medication which can completely offset the harm AI treatment could do to your bones.  But, you have to take it, and the sooner you start, the better.

Denosumab – Prolia – OPG Analog

August 21, 2014 @ 8:17 pm
posted by Dr Ginther

Denosumab (Prolia) mimics the natural process that keeps OsteoClasts (the cells that gobble up bone) under control before menopause.  OsteoCytes release Osteoprotegrin (OPG) when Estrogen (or Testosterone) is on board.  OPG controls the formation and activation of OsteoClasts by blocking RANK-Ligand, which is necessary for OsteoClast formation and activation.  This decreases fracture risk.

Modern Hormone Replacement Therapy (HRT)

August 7, 2014 @ 5:40 am
posted by Dr Ginther

Modern Hormone Replacement Therapy (HRT) is safe in most women through their 60′s.  20 years ago, when Progesterone was included in the formulation, HRT was associated with heart problems.  Estrogen alone in modern HRT avoids this issue, at least until age 70.  Recent studies have shown that modern HRT actually decreases heart disease deaths in women in their 50′s.

Modern HRT is most commonly used to treat menopausal symptoms.  However, human estrogen is what naturally preserves bone in a pre-menopausal woman.  Restoring human estrogen will also preserve bone in a post-menopausal women.  You can postpone Osteoclasts Gone Wild eating away your bones!