Posts Tagged ‘osteoclasts’
Aromatase Inhibitors (AI) do a great job treating Breast Cancers which are Estrogen dependent. The AI wipe out all Estrogen thereby depriving the breast cancer of a needed stimulus.
Unfortunately, Aromatase Inhibitor treatment will also do considerable damage to your bones unless you take medication to protect your bones. The good news is that we have medication which can completely offset the harm AI treatment could do to your bones. But, you have to take it, and the sooner you start, the better.
Denosumab (Prolia) mimics the natural process that keeps OsteoClasts (the cells that gobble up bone) under control before menopause. OsteoCytes release Osteoprotegrin (OPG) when Estrogen (or Testosterone) is on board. OPG controls the formation and activation of OsteoClasts by blocking RANK-Ligand, which is necessary for OsteoClast formation and activation. This decreases fracture risk.
Evista (Raloxifene) can both prevent breast cancer and prevent osteoporosis! Evista has been approved for both indications. Not often can a woman treat two dreaded conditions with a single pill.
Evista is very similar to human estrogen. Evista is an “Estrogen-Agonist-Antagonist”. That means Evista acts like natural human estrogen when it prevents osteoporosis. But Evista also blocks human estrogen when it prevents breast cancer.
Evista convinces the OsteoCytes that estrogen is on board. The OsteoCytes release Osteoprotegrin (OPG), which is the natural substance that keeps the OsteoClasts (the cells that gobble up your bone) from going wild. Your bone is preserved, just like it was before menopause. This action is just like Hormone Replacement Therapy (HRT).
The most common side effect of Evista is menopausal-like symptoms. Fortunately, these usually fade within 1 to 2 months. Rare side effects include a slight increase in blood clots in persons with a personal history of blood clots or a strong family history. We also suspect a slight increase in heart problems over the age of 70, as in HRT, but not enough women have taken Evista beyond the age of 70 to find out if this is true.
Evista is a daily pill with no heartburn or GERD issues. It preserves bone by stimulating the natural process of a premenopausal state. Evista prevents breast cancer. Evista is a great choice for women looking for that combination.
Take control of your future.
Jay Ginther, MD
Modern Hormone Replacement Therapy (HRT) is safe in most women through their 60′s. 20 years ago, when Progesterone was included in the formulation, HRT was associated with heart problems. Estrogen alone in modern HRT avoids this issue, at least until age 70. Recent studies have shown that modern HRT actually decreases heart disease deaths in women in their 50′s.
Modern HRT is most commonly used to treat menopausal symptoms. However, human estrogen is what naturally preserves bone in a pre-menopausal woman. Restoring human estrogen will also preserve bone in a post-menopausal women. You can postpone Osteoclasts Gone Wild eating away your bones!