Posts Tagged ‘Forteo’
Aunt Henrietta looked like half a raccoon with her entire left eye blackened. She dismissed her looks as not a problem saying, “I fall all the time, but I don’t break anything.” This is a change on both counts. Five years ago, falls were infrequent. Even so, she broke one wrist, then the other wrist, then her shoulder.
Two wrists, one shoulder, and half a dozen vertebral fragility fractures indicated Very Severe Osteoporosis. That was before she took the Anabolic, Forteo, for 2 years. She was the ideal patient for serious measures to stop her fractures. And it has worked!!
Aunt Henrietta is celebrating her 89th birthday, and 4 1/2 years without a fracture! This is a major victory for her. She is one of our many stars!
Despite starting on enough calcium and enough vitamin D over 6 years ago, Henrietta broke one wrist, then the other wrist, and finally a shoulder. Finally she added osteoporosis medications. Despite falling all the way down the attic stairs, she has not broken anything since.
GIOP is Glucocorticoid Induced OsteoPorosis. Cortisone, Prednisone, and many Inhalers for Asthma or COPD are glucocorticoids. Therefore, Glucocorticoid Induced OsteoPorosis is a particularly aggressive form of osteoporosis that affects all ages, not just older adults.
Glucocorticoids suppress OsteoBlasts, the cells that make new bone. Even the normal rate of bone turnover required for good bone maintenence and repair of microcracks becomes a problem when new bone formation is suppressed. Persons with GIOP have a rapid decline in bone quality and strength. What can be done?
This week I spoke to doctors and nurses who run Pain Clinics. The obvious connection is Vertebral Fractures requiring Kyphoplasty or Vertebroplasty. If you only do the procedure, you have not solved the problem. You must treat the Osteoporosis too, preferably with the Anabolic, Forteo, if you want to avoid further fractures.
Vitamin D is the other connection. Successful treatment of chronic pain often requires enough Vitamin D3 to bring the 25-hydroxy Vitamin D level to at least 40ng/ml. This is not yet widely known. Not all clinics are testing for Vitamin D levels. They should be!