Posts Tagged ‘Forteo’
If you fracture, your risk of a second fracture within a year is 3 to 5 times as great! If that first or second fracture is a hip, you have a 25% chance of dying and a 25% chance of spending the rest of your life in a nursing home. Scary.
Sometimes nutrition and lifestyle changes are enough. Often medications are needed to effect real improvement. The anabolic medications Teriparatide (Forteo), Abaloparatide (Tymlos), and Romosozumab (Evenity) not only prevent further fractures by increasing bone mass, but also speed healing. The antiresorptive medications decrease fracture risk by preventing bone loss.
The NOF video at https://vimeo.com/267839997 discusses the likelihood of benefit in relation to the very small risk of harm from antiresorptive medications.
Understand the relative risks of taking a medication compared to the relative risks involved in not taking a medication.
Jay Ginther, MD
Covid-19 is quite contagious. Patients coming into a clinic or hospital could put themselves at risk from other patients. Patients who are not yet symptomatic can put other patients and health-care workers at risk. How can we get essential medications, yet limit risk? Drive-Thru.
I am on several medications which cannot be stopped because I am controlling chronic diseases (that cannot be cured). I no longer enter my pharmacy. Drive-Thru window.
Osteoporosis is a chronic disease we cannot cure, but can control. We now call every Prolia and Evenity patient offering the option of being met in the parking lot.
Roll down the car window. Roll up your sleeve and put your arm out the window. Get your shot. Roll up your sleeve and window. Done with minimal exposure to another person.
Remember that skipping a Prolia shot is a very bad idea. Recently evidence has surfaced that missing a Prolia shot by more than 2 months can increase the risk of vertebral fracture to higher than it was before starting treatment.
Most of the time we can delay the DXA/VFA or lab tests by a month or 2 or even 6. Prolia and Evenity should not be delayed. Forteo and Tymlos usually arrive by mail for self injection. Changing to a different medication could be another option. Call your doc.
Jay Ginther, MD
National Bone Health treatment goals are changing for those patients with high fracture risk. Simply preserving bones already at a too high fracture risk never made much sense to this former orthopedic surgeon. Now the national leadership is stressing the need to lower fracture risk first, then preserve bones at a lower level of fracture risk.
We now have 3 anabolic medications which substantially lower fracture risk by increasing the thickness and strength of bone structure: Teriparatide (Forteo), Abaloparitide (Tymlos), and Romosozumab (Evenity). They all decrease fracture risk substantially more than the antiresorptive (preserving) medications alone. The difference in fracture risk grows for up to 5 years. After that the difference in fracture risk between anabolic meds followed by preserving meds vs. preserving meds alone remains the same.
Calcium can take up to 3 additional years to collect in newly formed bone matrix. DXA shows calcium in bone (Bone Mineral Density). Much of the increased BMD can only be seen on DXA after the anabolic med is completed and the antiresorptive med is started.
All of the anabolic medications must be followed by antiresorptive medication to preserve the gains made by the anabolic. No medication to grow or preserve bone can work without adequate nutrition in the form of absorbable calcium, vitamin D3, protein and other vitamins and minerals.
Jay Ginther, MD
Recently I wrote about our participation in a clinical trial offering the anabolic Tymlos (Abaloparatide) to men. Now we have been approved for participation in another Tymlos (Abaloparatide) trial – this one for women. Currently Tymlos is available to women as a daily shot. The new delivery system is a patch applied to the skin for 5 minutes daily. That is far more convenient than a shot.
The FDA compliant trial is being run by the Northeast Iowa Family Practice Center. They have years of experience with clinical trials. Clinical trials always have strict inclusion and exclusion criteria requiring extensive screening, interviews and multiple testings. All screening is free to the participant. If you are accepted into the trial, all treatment is also at no charge.
All participants will receive the FDA approved anabolic (increases bone matrix) medication Tymlos (Abaloparatide). Participants are randomized to the standard injection or the new patch.
Our participation in the study is that Bone Health will be doing all screening and quarterly study DXAs and ADI (Advanced Diagnostic Imaging of Iowa) will be doing the spine x-rays. We are also screening our own patients for potential to be study participants.
Remember that anabolic medications Forteo (Teriparatide), Tymlos (Abaloparatide), and Evenity (Romosozumab), primarily stimulate new bone formation. Antiresorptives Fosamax (Alendronate), Actonel/Atelvia (Risendronate), Boniva (Ibandronate), Reclast (Zolendronate), Evista (Raloxifene), and Prolia (Denosumab), primarily preserve bone.
Of course, all medications require proper nutrition to work well.
Jay Ginther, MD