Pharmaceutical Industry Websites

The following sites are sponsored by the manufacturers of these pharmaceutical agents:

Posts Tagged ‘Calcium’

Bone Mineral Density is Calcium in Bone

January 11, 2020 @ 11:20 am
posted by Dr Ginther

Why do some patients, who are already on good osteoporosis preventing or treating medications, still have a falling Bone Mineral Density?  Are the medications not working?  Not as well as they should!  Why?  Even the best medications cannot work without enough CALCIUM intake and absorption.

If you want to improve your bones you must ABSORB enough calcium.  This can be a bit tricky.  You need the right kind of calcium, taken in food or with food, and spread out over 3 meals or snacks.  “Calcium” is Calcium Carbonate which requires lots of acid to dissolve.  This often is a problem if you take antacids, have heartburn or GERD, have digestive issues like lactose sensitivity, celiac or IBS, or are just “too old”, which begins at 50.

Calcium in foods is easy to absorb.  Calcium Citrate tablets or Tricalcium Phosphate Gummies require 2 tablets or gummies to total the 400 or 500 or 600 mg on the label.  Adora Chocolates are 500 mg each.  We recommend taking in 1200-1500 mg calcium daily.  That means 400-500mg at each of 3 meals.

DXA does not show bones.  DXA shows calcium.  Calcium stiffens and strengthens bones.  You cannot have good BMD or good bones without enough calcium!  Take control of your bone health with adequate calcium in diet and supplements.

Next time a listing of Calcium in Foods

Jay Ginther, MD

Improve Bone First – Preserve Bone Second

December 8, 2019 @ 8:19 pm
posted by Dr Ginther

National Bone Health treatment goals are changing for those patients with high fracture risk.  Simply preserving bones already at a too high fracture risk never made much sense to this former orthopedic surgeon.  Now the national leadership is stressing the need to lower fracture risk first, then preserve bones at a lower level of fracture risk.

We now have 3 anabolic medications which substantially lower fracture risk by increasing the thickness and strength of bone structure: Teriparatide (Forteo), Abaloparitide (Tymlos), and Romosozumab (Evenity).  They all decrease fracture risk substantially more than the antiresorptive (preserving) medications alone.  The difference in fracture risk grows for up to 5 years.  After that the difference in fracture risk between anabolic meds followed by preserving meds vs. preserving meds alone remains the same.

Calcium can take up to 3 additional years to collect in newly formed bone matrix.  DXA shows calcium in bone (Bone Mineral Density).   Much of the increased BMD can only be seen on DXA after the anabolic med is completed and the antiresorptive med is started.

All of the anabolic medications must be followed by antiresorptive medication to preserve the gains made by the anabolic.  No medication to grow or preserve bone can work without adequate nutrition in the form of absorbable calcium, vitamin D3, protein and other vitamins and minerals.

Jay Ginther, MD

Treating Fibromyalgia with Nutrition

March 31, 2018 @ 8:09 pm
posted by Dr Ginther

I was asked about treatments for Fibromyalgia.  Pain clinics have injections and pharmaceuticals that often help, but not always enough.  I approach from a different angle.

Fibromyalgia is a collection of many different maladies that are  magnifying each other.  They are very difficult to untangle.  Treating all aspects of the pain is the key to success.

I have actually “cured” fibromyalgia only 4 times, but usually I can decrease the pain enough that other measures will work better than before. 

The key is understanding that pain often is nerves misbehaving, magnifying the intensity of unpleasant stimuli.  This is neuropathy or neuralgia.  These conditions are made much worse by nutritional deficits.

B1, B6, B12 and Folate are key nutrients for nerve function.  Controlling diabetes is also important.  Low calcium, potassium or magnesium cause cramping and pain.  These should ALL be checked.

Vitamin D is often overlooked as essential for nerve function.  Low vitamin D will cause depression, malaise, nerve malfunction and increased pain.  I aim for a vitamin D level of 70 ng/ml – higher than needed for bone health, but completely safe.  If your level is very low you may need megadoses, well above 5000 IU daily.

Take Control Naturally with Vitamin D3, as well as B1, B6, B12, Folate, Calcium, Potassium and Magnesium.

Jay Ginther, MD

Treat to Target #6 – Treatment

February 27, 2018 @ 7:07 pm
posted by Dr Ginther

Our goal is NO NEW FRACTURES.  Therefore, Treat to Target means a FRAX score of <20% for “major osteoporotic” and <3% for hip fracture.  Alternately, T-score of better than -1.5 if there are any fractures.

Antiresorptives do not substantially increase bone mass or BMD.  While a 3-5% BMD improvement can be seen when a long term deficiency in calcium absorption is corrected, the function of an antiresorptive is to maintain current bone mass.

If you want to substantially increase bone mass, you must use an anabolic medication.  We now have 2.  Forteo (teriparatide) has been available for 15 years.  Tymlos (abaloparatide) was approved late last spring, but has only achieved good coverage by a majority of insurance companies in the last month.

Both can be given for up to 24 months.  Both must be followed by an antiresorptive to avoid loss of gains.  Both will show continued improvement in BMD for up to 3 years after switching to an antiresorptive because calcium takes up to 3 years to fully accumulate in new bone matrix formed by an anabolic.

Both should NOT be given to anyone with open growth plates, Paget’s, radiation to bone, cancers which have or could spread to bone, elevated bone specific alkaline phosphatase other than from fracture healing, or pregnant or nursing women.

Tymlos is approved for postmenopausal women only.  It does not stimulate bone turnover significantly and therefore shows faster BMD increase initially in the hip.  It has not been tested for use after antiresorptives.

Forteo is approved for men and women with osteoporosis which is “age-related”, or from steroid use, or from idiopathic hypogonadism.  Forteo significantly increases both osteoblast and osteoclast activity, thereby stimulating bone turnover, which is often suppressed after long-term antiresorptives.  Forteo is the default treatment for ONJ and AFF.

If you are dealing with vertebral fractures on VFA, or really low BMD on DXA, or with multiple fragility fractures, you need an ANABOLIC FIRST, to decrease fracture risk.  Then follow with antiresorptives to maintain a low enough fracture risk.

Remember, even these medications will fail without proper nutrition.

jay Ginther, MD