Posts Tagged ‘Bone Turnover’

Several patients have concerns about oral surgery while taking Prolia.  This is not a problem – if you follow guidelines.

Prolia is different from other Antiresorptives.  Prolia does not accumulate in bone.  5 to 6 months after your last dose, Prolia has lost its effect of slowing bone turnover.  Therefore, it is safe to proceed with surgery on bone (including dental surgery) 6 months after your last dose.

Patients worry about OsteoNecrosis of the Jaw (ONJ), but this is very rare.  In fact ONJ virtually never occurs without a tooth extraction or serious periodontal disease.  Even then, it is rare unless you also have cancer,  have poorly controlled diabetes, or are seriously Deficient in Vitamin D3, or Calcium, or Protein intake.

Elective Orthopedic Surgery timing is the same.  If you need a Total Hip Replacement (THR) or Total Knee Replacement (TKR), schedule the surgery for 6 months after your last dose of Prolia.

Any time you plan to have surgery on bone, you should Optimize Your Bone Health First.  Get a Complete Bone Health Evaluation.  Optimize your Vitamin D level (at 40 to 80 ng/ml).  Optimize your Calcium intake in foods and supplements combined (at 400 to 500 mg at all 3 meals daily).  Optimize your daily Protein intake (1 g Protein for every kg body weight).

Sometimes you will also need the Anabolic, Forteo, to increase bone matrix and improve healing.  More about that another time.

Get the best possible result from orthopedic or dental surgery.  Wait 6 months after Prolia, and do your part to optimize your bone health.

Jay Ginther, MD

Osteoporosis Medications Reviewed

February 9, 2015 @ 6:32 pm
posted by Dr Ginther

Recently a patient asked me to review all osteoporosis medications for her to consider and choose from.  We had already optimized her Calcium intake, 25-hydroxy Vitamin D level, Protein intake, Multiple Vitamins & Minerals, and Exercise program.  These had all helped substantially, but not enough for her peace of mind.  She feels that she needs osteoporosis medication too.  Here they are:

Forteo Increases Bone Thickness on the Inside

October 9, 2014 @ 5:19 pm
posted by Dr Ginther

Forteo (Teriparatide) increases the thickness of the struts making up spongy (cancellous) bone.  Forteo is the only osteoporosis medication to do that.  It also makes the hard outer shell (cortical bone) thicker.  How?  Forteo stimulates OsteoBlasts.  They make bone matrix, the collagen protein that is more than 80% of bone.

Forteo also stimulates bone turnover.  Healthy bone is constantly being resorbed and replaced.  This allows bone to eliminate the micro-cracks that gradually accumulate with activity.  Bone is strongest when it is a mixture of older more calcified (stiffer) material mixed thoroughly with younger less calcified (somewhat bendable) material.  Cracks cannot enlarge.  Strength is better.  More force is required to fracture the bone.

Bisphosphonates accumulate in your bone.  When OsteoClasts gobble up your bone, bisphosphonates are released into the Osteoclasts and disable or kill the Osteoclasts.  This is great news when the problem is Osteoclasts Gone Wild.  Bisphosphonates preserve bone by slowing down bone resorption.  However, after a few months, bone formation by OsteoBlasts also slows down, resulting in slow bone turnover.

Moderate and balanced bone turnover is good.  You repair microcracks in your bone when OsteoClasts resorb the bone around them and OsteoBlasts fill in the void with new bone matrix.  A mix of new and old bone is far stronger than all old bone.  Some OsteoClast activity is necessary to heal fractures, especially incomplete (stress) fractures.  That is where long term bisphosphonates can be too much of a good thing.