Posts Tagged ‘Bone Matrix’

Prevent and Treat ONJ with Forteo

July 31, 2015 @ 7:54 am
posted by Dr Ginther

Dentists and Oral Surgeons are sometimes wary of their patients being on ANY Osteoporosis Medications when they undergo tooth extractions or other dental proceedures.  One osteoporosis medication is different from all the others.  Forteo is the only Anabolic medication currently available in the USA.  Forteo does not cause dental and jaw problems.  Forteo can be used to treat ONJ and other bone problems of the jaw.

OsteoNecrosis of the Jaw (ONJ) is a rare complication of tooth extraction.  If you have cancer, are on chemotherapy, have uncontrolled diabetes, or are on the higher doses of Antiresorptive Osteoporosis Medications used in Cancer Patients with Metastases, ONJ is less rare.

ONJ is the result of too slow bone repair by the OsteoBlasts (the cells that make new bone matrix).  Antiresorptive medications slow down both OsteoClasts (the cells that resorb bone) and OsteoBlasts.

Forteo cannot cause ONJ.  Forteo (Teriparatide) stimulates OsteoBlasts.  That increases new bone matrix formation.  Therefore, Forteo can prevent and treat ONJ.

Forteo has been shown to improve bone healing in dental surgery, including implant osseointegration and healing alveolar defects.  Ref:  Batshutski JD, Eber RM, Kinney JS, et al.  Teriparatide and osseous regeneration in the oral cavity.  N Engl J Med. 2010, 363:2396-2405.  Ref:  Kuchler U, Luvizuto ER, Tangl S, et al.  Short-term Teriparatide delivery and osseointegration: a clinical feasibility study.  J Dent R. 2011:90(8):1001-1006.

As a former orthopedic surgeon, I have discussed these issues with several of our local oral surgeons and dentists.

If you are facing oral surgery or tooth extraction, discuss your osteoporosis medications with your dental surgeon.  Most osteoporosis medications should be held for your surgery.  Forteo is the exception.  Forteo actually helps your jaw heal after dental surgery.

Jay Ginther, MD

Several patients have concerns about oral surgery while taking Prolia.  This is not a problem – if you follow guidelines.

Prolia is different from other Antiresorptives.  Prolia does not accumulate in bone.  5 to 6 months after your last dose, Prolia has lost its effect of slowing bone turnover.  Therefore, it is safe to proceed with surgery on bone (including dental surgery) 6 months after your last dose.

Patients worry about OsteoNecrosis of the Jaw (ONJ), but this is very rare.  In fact ONJ virtually never occurs without a tooth extraction or serious periodontal disease.  Even then, it is rare unless you also have cancer,  have poorly controlled diabetes, or are seriously Deficient in Vitamin D3, or Calcium, or Protein intake.

Elective Orthopedic Surgery timing is the same.  If you need a Total Hip Replacement (THR) or Total Knee Replacement (TKR), schedule the surgery for 6 months after your last dose of Prolia.

Any time you plan to have surgery on bone, you should Optimize Your Bone Health First.  Get a Complete Bone Health Evaluation.  Optimize your Vitamin D level (at 40 to 80 ng/ml).  Optimize your Calcium intake in foods and supplements combined (at 400 to 500 mg at all 3 meals daily).  Optimize your daily Protein intake (1 g Protein for every kg body weight).

Sometimes you will also need the Anabolic, Forteo, to increase bone matrix and improve healing.  More about that another time.

Get the best possible result from orthopedic or dental surgery.  Wait 6 months after Prolia, and do your part to optimize your bone health.

Jay Ginther, MD

Forteo Increases Bone Thickness on the Inside

October 9, 2014 @ 5:19 pm
posted by Dr Ginther

Forteo (Teriparatide) increases the thickness of the struts making up spongy (cancellous) bone.  Forteo is the only osteoporosis medication to do that.  It also makes the hard outer shell (cortical bone) thicker.  How?  Forteo stimulates OsteoBlasts.  They make bone matrix, the collagen protein that is more than 80% of bone.

Forteo also stimulates bone turnover.  Healthy bone is constantly being resorbed and replaced.  This allows bone to eliminate the micro-cracks that gradually accumulate with activity.  Bone is strongest when it is a mixture of older more calcified (stiffer) material mixed thoroughly with younger less calcified (somewhat bendable) material.  Cracks cannot enlarge.  Strength is better.  More force is required to fracture the bone.

Anabolic Medications Make New Bone

October 6, 2014 @ 7:51 am
posted by Dr Ginther

Anabolic medication for osteoporosis actually increases bone thickness and strength!  Antiresorptive medications for osteoporosis (Fosamax, Alendronate, Actonel, Atelvia, Boniva, Evista, Reclast, Prolia) only preserve bone.

We have talked about all of the Antiresorptive medications over the last 2 months.  They are excellent treatment if slowing down the OsteoClasts (cells that eat away your bone) is sufficient.  That is not always the case.

Now it is time to talk about something completely different.  Anabolic medication stimulates the OsteoBlasts (cells that make new bone matrix).  OsteoBlasts can rebuild your bones.  If you have Fractures, your bones may need to be rebuilt.

Forteo (Teriparatide) is the only Anabolic medication for osteoporosis in the USA.  Close cousins of Forteo are available in other countries.

You may need the Anabolic, Forteo, if you have a hip fracture, multiple other fractures, or if VFA testing reveals a Vertebral Compression Fracture.  A DXA T-score well below -2.5 can be reason enough without fracture.

Glucocorticoid (Cortico-Steroid) medications (Prednisone, Steroid Inhalers) specifically supress OsteoBlasts (cells that make new bone).  Stimulating the OsteoBlasts with the Anabolic, Forteo, can offset the bone loss from Steroid medications.  Smoking also supresses OsteoBlasts, leading to bone loss.  Stopping Smoking would be best, but Forteo can help.

Not everyone needs an Anabolic, but some individuals do.  A Complete Bone Health Evaluation will tell you if an Anabolic is right for you.

More about Forteo (Teriparatide) next time.

Jay Ginther, MD