Posts Tagged ‘antiresorptive’
Forteo (Teriparatide) increases the thickness of the struts making up spongy (cancellous) bone. Forteo is the only osteoporosis medication to do that. It also makes the hard outer shell (cortical bone) thicker. How? Forteo stimulates OsteoBlasts. They make bone matrix, the collagen protein that is more than 80% of bone.
Forteo also stimulates bone turnover. Healthy bone is constantly being resorbed and replaced. This allows bone to eliminate the micro-cracks that gradually accumulate with activity. Bone is strongest when it is a mixture of older more calcified (stiffer) material mixed thoroughly with younger less calcified (somewhat bendable) material. Cracks cannot enlarge. Strength is better. More force is required to fracture the bone.
Anabolic medication for osteoporosis actually increases bone thickness and strength! Antiresorptive medications for osteoporosis (Fosamax, Alendronate, Actonel, Atelvia, Boniva, Evista, Reclast, Prolia) only preserve bone.
We have talked about all of the Antiresorptive medications over the last 2 months. They are excellent treatment if slowing down the OsteoClasts (cells that eat away your bone) is sufficient. That is not always the case.
Now it is time to talk about something completely different. Anabolic medication stimulates the OsteoBlasts (cells that make new bone matrix). OsteoBlasts can rebuild your bones. If you have Fractures, your bones may need to be rebuilt.
Forteo (Teriparatide) is the only Anabolic medication for osteoporosis in the USA. Close cousins of Forteo are available in other countries.
You may need the Anabolic, Forteo, if you have a hip fracture, multiple other fractures, or if VFA testing reveals a Vertebral Compression Fracture. A DXA T-score well below -2.5 can be reason enough without fracture.
Glucocorticoid (Cortico-Steroid) medications (Prednisone, Steroid Inhalers) specifically supress OsteoBlasts (cells that make new bone). Stimulating the OsteoBlasts with the Anabolic, Forteo, can offset the bone loss from Steroid medications. Smoking also supresses OsteoBlasts, leading to bone loss. Stopping Smoking would be best, but Forteo can help.
Not everyone needs an Anabolic, but some individuals do. A Complete Bone Health Evaluation will tell you if an Anabolic is right for you.
More about Forteo (Teriparatide) next time.
Jay Ginther, MD
This weekend is Aunt Henrietta’s 90th birthday. I have just the right gift for her, Adora Premium Chocolates. My Aunt Henrietta has been our posterchild since the beginning of Cedar Valley Bone Health Institute of Iowa. Her adventures are well chronicled.
I had to tell her Endocrinologist about the Anabolic, Forteo. She agreed to give herself a daily shot. Then she proved that treatment had worked by falling down the stairs and not breaking anything.
Finally she locked in the gains of Forteo by starting the Antiresorptive that gets along with her severe GERD and aging kidneys, Prolia.
She can live alone in her own home because she Took Control of her bone health, with Calcium, Vitamin D3, Protein, Multiple Vitamins and Minerals, and Osteoporosis Medications. They are all necessary.
Happy Birthday Aunt Henrietta!
Jay Ginther, MD
Modern Hormone Replacement Therapy (HRT) is safe in most women through their 60’s. 20 years ago, when Progesterone was included in the formulation, HRT was associated with heart problems. Estrogen alone in modern HRT avoids this issue, at least until age 70. Recent studies have shown that modern HRT actually decreases heart disease deaths in women in their 50’s.
Modern HRT is most commonly used to treat menopausal symptoms. However, human estrogen is what naturally preserves bone in a pre-menopausal woman. Restoring human estrogen will also preserve bone in a post-menopausal women. You can postpone Osteoclasts Gone Wild eating away your bones!