Posts Tagged ‘anabolic’
Are your bones still good enough and just need to be maintained? Or have you fractured several times and need to rebuild your bones? Are Steroid Inhalers supressing your Osteoblasts – the cells that build new bone? (not good) Or have your Osteoclasts – the cells that eat away bone – gone wild (even worse) now that you are post-menopausal or an older guy?
Different problems require different classes of medication. Bisphosphonates, Hormone Replacement Therapy, Synthetic Estrogen Receptor Modifier – Evista, and RANK-Ligand Antibody – Prolia, are all Antiresorptives, which act in different ways. They slow down the Osteoclasts that have gone wild and are eating up the bone. The Anabolic, Forteo, stimulates the Osteoblasts that make new bone matrix. Antiresorptive and Anabolic are radically diferent actions.
Patients who have already fractured may need osteoporosis medications. Adding fractures to a low BMD or T-score on DXA makes the Clinical Osteoporosis more severe and increases Fracture Risk. This is true of vertebral fractures detected on VFA, as well as clinically obvious fractures, like hip or wrist or shoulder.
Fracture Risk is the big deal. Fractures are what we want to avoid. Having suffered one fracture makes a Second Fracture 3 to 5 times as likely as the first. Bummer. Calcium, Vitamin D, Protein, Multivits and Exercise alone often cannot overcome those odds. Real bummer. Adding a medication often can avoid the Second Fracture.
Aunt Henrietta looked like half a raccoon with her entire left eye blackened. She dismissed her looks as not a problem saying, “I fall all the time, but I don’t break anything.” This is a change on both counts. Five years ago, falls were infrequent. Even so, she broke one wrist, then the other wrist, then her shoulder.
Two wrists, one shoulder, and half a dozen vertebral fragility fractures indicated Very Severe Osteoporosis. That was before she took the Anabolic, Forteo, for 2 years. She was the ideal patient for serious measures to stop her fractures. And it has worked!!
Aunt Henrietta is celebrating her 89th birthday, and 4 1/2 years without a fracture! This is a major victory for her. She is one of our many stars!
Despite starting on enough calcium and enough vitamin D over 6 years ago, Henrietta broke one wrist, then the other wrist, and finally a shoulder. Finally she added osteoporosis medications. Despite falling all the way down the attic stairs, she has not broken anything since.