GIOP is Glucocorticoid Induced OsteoPorosis. Cortisone, Prednisone, and many Inhalers for Asthma or COPD are glucocorticoids. Therefore, Glucocorticoid Induced OsteoPorosis is a particularly aggressive form of osteoporosis that affects all ages, not just older adults.
Glucocorticoids suppress OsteoBlasts, the cells that make new bone. Even the normal rate of bone turnover required for good bone maintenence and repair of microcracks becomes a problem when new bone formation is suppressed. Persons with GIOP have a rapid decline in bone quality and strength. What can be done?
In nature, green things are springing from the dead earth. Jews celebrate Passover, the rebirth of the Jewish people as a nation instead of laborers in Egypt. Christians celebrate Easter, and Jesus rising from death. Other religions have similar festivals of rebirth and renewal.
“The Blue Zones” and “Thrive” both documented that religious beliefs and practices are associated with longer and happier lives. Whether people focus on Jehovah, God, Christ, Allah, Vishnu, Buddha, or another human explanation of the devine is apparently less important than the fact that they do believe and lead their lives accordingly.
Faced with a multi-hour “weather delay” Sunday returning from the ISCD meeting in Florida, I wandered through the airport bookstore looking for something interesting. My brain was full of information from the presentations, so I wanted something easy to read and fun. I found the latest book by Gavin Menzies.
“1421: the year China discovered America” was his first book. He assembled evidence that the Chinese had circumnavigated the world in 1421-24, charting the Straits of Magellan. His next book “1434: the year the magnificent Chinese fleet sailed to Italy and ignited the Renaissance” tells of knowledge brought to Italy (including maps showing the Americas) well before 1492.
Vertebral Fracture Assessment (VFA) identifies many persons with Clinical Osteoporosis who are missed by DXA testing alone. How many? I reviewed my first 941 patients to have VFA with their DXA (Feb 2010 – Sept 2012). I was amazed.
25% of the total had at least one Genant grade 2 or 3 Vertebral Deformity on VFA but were not identified as Osteoporosis by DXA. This is Clinical Osteoporosis missed by DXA alone in 25% of my total patients.