Running your butt off several days weekly, as a child, is good for your bones. And the benefits last a lifetime!
We already knew that vigorous running sports can produce a peak bone mass and bone size at least 50% better than couch potatoes’. Now a study, in the Scandinavian Journal of Medicine and Science in Sports, of elderly individuals has shown that these traits persist long after retirement from sports. Fracture rates and Fracture Risk are also lower in former athletes.
This weekend is Aunt Henrietta’s 90th birthday. I have just the right gift for her, Adora Premium Chocolates. My Aunt Henrietta has been our posterchild since the beginning of Cedar Valley Bone Health Institute of Iowa. Her adventures are well chronicled.
I had to tell her Endocrinologist about the Anabolic, Forteo. She agreed to give herself a daily shot. Then she proved that treatment had worked by falling down the stairs and not breaking anything.
Finally she locked in the gains of Forteo by starting the Antiresorptive that gets along with her severe GERD and aging kidneys, Prolia.
She can live alone in her own home because she Took Control of her bone health, with Calcium, Vitamin D3, Protein, Multiple Vitamins and Minerals, and Osteoporosis Medications. They are all necessary.
Happy Birthday Aunt Henrietta!
Jay Ginther, MD
Aromatase Inhibitors (AI) do a great job treating Breast Cancers which are Estrogen dependent. The AI wipe out all Estrogen thereby depriving the breast cancer of a needed stimulus.
Unfortunately, Aromatase Inhibitor treatment will also do considerable damage to your bones unless you take medication to protect your bones. The good news is that we have medication which can completely offset the harm AI treatment could do to your bones. But, you have to take it, and the sooner you start, the better.
Prolia (Denosumab for Osteoporosis) is specifically approved by the FDA for use in patients using Aromatase Inhibitors (AI) for their breast cancer. Prolia is specifically for women without metastases. Prolia can delay and/or prevent matastases when given early. Xgeva (Denosumab for Cancer) is used if metastases are already present.
Denosumab (Prolia) mimics the natural process that keeps OsteoClasts (the cells that gobble up bone) under control before menopause. OsteoCytes release Osteoprotegrin (OPG) when Estrogen (or Testosterone) is on board. OPG controls the formation and activation of OsteoClasts by blocking RANK-Ligand, which is necessary for OsteoClast formation and activation. This decreases fracture risk.
Prolia mimics OPG and blocks RANK-Ligand, thus blocking bone resorption by preventing OsteoClasts. It is a RANK-Ligand Antibody. It is like birth control for OsteoClasts. Prolia is given as a shot under the skin twice a year. Prolia is very effective at first, but begins to fade by 6 months. Without another injection , Prolia has totally lost effectiveness by 12 months after the last shot.