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Osteoclasts Gone Wild

January 25, 2011 @ 5:00 pm
posted by Dr Ginther

Osteoclasts are the cells that eat away bone.  Osteoclasts are normally kept under control by Estrogen in women and Testosterone in men.  Women suddenly lose Estrogen at Menopause.  Men gradually lose Testosterone over time.  Osteoclasts are like misbehaving teenagers. Once the control is lost, it is “Osteoclasts Gone Wild”.

Steroid medicines in pills or inhalers for asthma or other diseases can block the controls on Osteoclasts.  Smoking also allows bone to be eaten away faster.

Osteoporosis happens when bone is eaten away faster than bone is formed by the cells that make new bone matrix, the Osteoblasts.  We need to restore the balance of bone formation and resorption to treat or prevent Osteoporosis.  We have several options:

1.  Slow down the Osteoclasts – Antiresorptives

2.  Disable or Kill the Osteoclasts – Bisphosphonates

3.  Prevent Osteoclast Formation and Activation – RANK-Ligand Blocker – Prolia – Denosumab

4.  Reassert Hormonal Control – Modern Hormone Replacement Therapy

Estrogen-Agonist-Antagonist –Evista – Raloxifene

Testosterone for Men

5.  Speed up Bone Matrix Formation – the AnabolicForteo – Teriparatide

Jay Ginther, MD

Copyright November 2010

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